Mission

Inventing advanced reagents and software for genomic analysis

from patented genome bioinformatic technologies:

Shannon pipeline software is used for high throughput interpretation of genomic variation:

• High accuracy prediction of  functional non-coding variants. Currently available for splicing mutations. In the future, transcription factor binding site variants and mutations in untranslated regions.
• Genome scale performance, but hones in on a small number of functionally significant variants.
• Proven approach based on information theory.
• Rapid results.
• For use with CLC bio’s user-friendly Genomics Workbench and Server platforms

Introduction to this revolutionary product …

Single Copy (sc) technology: precise, sensitive, and informative genomic hybridization tools for genetic disease management.

Products include:

• Fluorescent in-situ hybridization (scFISH) probes  from our catalog or custom synthesized.  scFISH probes offer the highest resolution available on the market.
• Low noise, genomic microarray designs for comparative genomic hybridization. Our genomic microarrays use sc technology to increase reproducibility and reduce cost per sample.
• Targeted solution capture arrays for hybridization enrichment with increased coverage for deep sequencing. Our solution capture arrays offer the highest genomic coverage available on the market for next generation sequencing.

Imaging chromosome abnormalities: Cytognomix has developed proprietary  image analysis algorithms and software to automatically detect chromosome abnormalities found by light and fluorescence microscopy.  Cytogenetic abnormalities are detected regardless of their appearance, shape or structure.  An example is our software for detecting dicentric chromosomes in blood, which are diagnostic for ionizing radiation exposures.

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Products

Shannon pipeline:

Genome-scale interpretation of mutations (Try it now!)

Software to predict splicing mutations along a chromosome

 

 

 

 

 

 

 

 

Hybridization Capture Arrays for Complete Gene Sequencing

Patented capture array content containing complete sequences of 7 breast cancer genes

 

 

 

 

 

 

 

 

 

Standard SC-FISH probes

DNA Probes previously verified by FISH research on congenital disorders, leukemia and other cancers.

Request probes

Genomic microarrays

Array CGH is commonly used to identify chromosome abnormalities by

genome-wide assessment of  copy number. Systematic noise in microarray

data is diminished:

• More accurate and reproducible results from your products
• Higher quality data for regulatory filings
• Fewer probes required to call copy number genotypes-
• Potentially more samples per array— use of sectored arrays with lower per sample costs

Have us design your microarray

Customized SC-FISH probes

Access Cytognomix’s SC-Genome Browser

Probes based on chromosome coordinate, gene, chromosomal band, and other characteristics. Manufactured on demand.

Contact us for browser access*