October 17, 2012. Automating cytogenetic biodosimetry

Cytognomix has established  partnerships to develop advanced high throughput software and microscope systems to automate cytogenetic biodosimetry in the event of a mass casualty radiation event. Biodosimetry laboratory partners include Health Canada and Atomic Energy of Canada Ltd. Software development for image processing of chromosome images is being carried out at the Schools of Engineering and Schulich School of Medicine and Dentistry, Western University, Ontario CA. We are providing software to Huron Technologies International, Waterloo CA to accelerate the detection of  dicentric metaphase chromosomes using a modification of their MACROscope system. The project has been supported by a Western Innovation Grant, a CMCR pilot project (NIH subcontract from Dartmouth University), and by the Federal Development Agency of Southern Ontario.

Read this description of our project with Huron Technologies:   ApplicationNote_cytogenetic_biodosimetry

June 26, 2012. New US Patent

FISH of short cancer related genesUS Patent 8,209,129 has issued on single copy DNA probes which include divergent repetitive sequences, thus significantly extending the portions of the genome that can be used for such probes beyond traditional single copy sequences.

The technology also increases the density of genomic DNA probes for higher resolution genetic analysis beyond what is used in FISH, genomic microarrays for array comparative genomic hybridization, and solution capture hybrdization arrays for sequence enrichment in deep sequencing. It is licensed to Cytognomix.

April 24, 2012. Mutation interpretation in deep sequencing data

Cytognomix’s new software product, the Shannon pipeline for human splicing mutation analysis of NGS sequencing data was presented at the BioIT World Conference and Expo (Apr 24-26, 2012), Boston.

Dr. Rogan describes our poster:

Large scale interpretation and stratification of non-coding sequence variants in the human genome. Ben Shirley1,Eliseos Mucaki2, & Peter Rogan1,2,3. Depts of Computer Science1 and Biochemistry2, and Cytognomix Inc3, London ON, Canada.