US Pat. No.8,407,013 issued: “Ab initio generation of single copy probes”.
This patent covers single copy probes that also contain divergent repetitive sequences, which under certain conditions, hybridize like single copy sequences. This expands the human genomic real estate accessible for single copy genomic analysis techniques. Cytognomix has used this approach to produce FISH probes in regions that could not be accessed by repeat masking, genomic microarrays, and capture arrays for next generation sequencing.
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