Collaboration with a French consortium to study non-coding variants in BRCA1 and BRCA2 in patients with a family history of breast and ovarian cancer:

Santana dos Santos, E, Caputo, S.M., Castera, L, Gendrot, M, Briaux, A., Breault, M, Krieger, S, Rogan, P.K, Mucaki, E.J., Bieche, I, Houdayer, C, Vaur, D, Stoppa-Lyonnet, D, Brown, M, Lallemand, F., Rouleau, E. Assessment of functional impact of germline BRCA1/2 variants located in noncoding regions in families with breast and or ovarian cancer predisposition, Breast Cancer Research and Treatment, in press.

The International Atomic Energy Agency (IAEA), within the recently initiated Coordinated Research Project: “Applications of Biological Dosimetry Methods in Radiation Oncology, Nuclear Medicine, Diagnostic and Interventional Radiology” (E35010) will develop clinical applications for biodosimetric techniques, in particular the dicentric assay. Many of the coordinating groups have developed the dicentric assay in their labs, but generally results are interpreted manually.

Clinical applications of biodosimetric techniques will only be routinely applied if less manpower-intensive techniques are employed. The Cytognomix ADCI software system addresses this critical need.

At the first meeting of the Research Coordinators of E35010, all respondents elected to receive evaluation versions of this software: