Our previous preprint in bioRxiv on centromere detection has been published in F1000Research:
Subasinghe A, Samarabandu J, Li Y et al. Centromere detection of human metaphase chromosome images using a candidate based method. F1000Research 2016, 5
Our paper, “Radiation Dose Estimation by Automated Cytogenetic Biodosimetry” by Peter K. Rogan, Yanxin Li, Ruth Wilkins, Farrah N. Flegal, and Joan H. M. Knoll, has been accepted for publication in the journal Radiation Protection Dosimetry.
Figure 1. Representative processed metaphase image in ADCI:
- Peter K. Rogan, Yanxin Li, Ruth Wilkins, Farrah Flegal, Joan HM Knoll. Radiation Dose Estimation by Automated Cytogenetic Biodosimetry, Great Lakes/Canadian Bioinformatics Conference (CCBC/GLBIO). May 16, 2016. University of Toronto (Platform Presentation).
- Peter K. Rogan. Radiation Dose Estimation by Automated Cytogenetic Biodosimetry. Platform presentation. Great Lakes Chromosome Conference. May 20, 2016. University of Toronto.
- Peter K. Rogan. Cisplatin Response Prediction in Recurrent Bladder Cancer using Biochemically-inspired Machine Learning. Oral and Poster presentations. 3rd International Molecular Pathological Epidemiology Meeting. May 13, 2016. Dana-Farber Cancer Institute, Boston.
- Rezaeian I, Mucaki E, Baranova K, Quang HP, Angelov D, Ilie L, Ngom A, Rueda L, Rogan PK. Predicting outcome of hormone and chemotherapy in the METABRIC breast cancer study. Great Lakes/Canadian Bioinformatics Conference (GLBIO/CCBC). May 16, 2016. University of Toronto.
- Baranova K, Mucaki EJ, Angelov D, Lizotte D, and Rogan PK. Cisplatin Response Prediction in Recurrent Bladder Cancer using Biochemically-inspired Machine Learning. Great Lakes/Canadian Bioinformatics Conference (GLBIO/CCBC). May 16, 2016. University of Toronto.
- Lu R and Rogan PK. Predicting cis-regulation in human promoters by information density-based clustering of heterotypic transcription factor binding sites. Great Lakes/Canadian Bioinformatics Conference (GLBIO/CCBC). May 16, 2016. University of Toronto.
The University of Western Ontario has issued a press release about our studies describing a unified framework for prioritization of mutations in breast and ovarian cancer.
Other press outlets:
- Medical Xpress
- Science Newsline
- Science Codex
- Ovarian cancer and us
April 26, 2016. Grant funding received for chromosome structure studies using Cytognomix ab initio scDNA probes
Discovery Grant from Natural Sciences and Engineering Research Council received for “Unravelling the metaphase epigenome: Differences in DNA accessibility between homologous chromosomes.” Joan Knoll, Principal Applicant and Peter Rogan, Co-applicant have been awarded 5 years of funding (2016-21) for this project.
April 11, 2016. New paper on analysis of variants of uncertain significance in hereditary breast & ovarian cancer
Our paper, which describes a generalized information theory-based approach for mutation analysis of protein-nucleic binding sites, has been published:
Mucaki, E, Caminsky N, Perri A, Lu R, Laederach A, Halvorsen, M, Knoll, JHM, Rogan PK. A unified analytic framework for prioritization of non-coding variants of uncertain significance in heritable breast and ovarian cancer, BMC Medical Genomics, 9:19, 2016. DOI: 10.1186/s12920-016-0178-5. (link to paper) (PubMed citation)
March 29, 2016. New publication on cost effectiveness of gene expression microarray testing in cancer diagnosis
Through a pan-Canadian collaboration led by Greg Zaric, we have published:
Cost-effectiveness of using a gene expression profiling test to aid in identifying the primary tumour in patients with cancer of unknown primary. M B Hannouf, E Winquist, S M Mahmud, M Brackstone, S Sarma, G Rodrigues, P Rogan, J S Hoch and G S Zaric.
The Pharmacogenomics Journal advance online publication 29 March 2016; doi: 10.1038/tpj.2015.94 (Link)
March 23, 2016. Final version of article about prioritizing mutations in inherited breast cancer is online
Peer-reviewed article in Early View in the journal Human Mutation: Link
Cytognomix pre-qualifies for funding from Build in Canada Innovation Program. Our proposal to test the Automated Dicentric Chromosome Identifier with Health Canada and Canadian Nuclear Laboratories has been approved by Public Works and Government Services Canada (link).
March 10, 2016. New paper accepted on prioritization strategy for gene variants of uncertain significance in breast/ovarian cancer
“A unified analytic framework for prioritization of non-coding variants of uncertain significance in heritable breast and ovarian cancer,” by
Eliseos J. Mucaki; Natasha G. Caminsky; Ami M. Perri; Ruipeng Lu; Alain Laederach; Matthew Halvorsen; Joan H.M. Knoll; and Peter K. Rogan
has been accepted for publication in the journal, BMC Medical Genomics.
A preprint of this article is currently available at BioRxiv: http://biorxiv.org/content/early/2015/11/11/031419.
Our new paper on interpretation of gene variants in inherited breast and ovarian cancer has been accepted for publication in the journal, Human Mutation as a Research Article.
“Prioritizing variants in complete Hereditary Breast and Ovarian Cancer (HBOC) genes in patients lacking known BRCA mutations,” by Natasha G. Caminsky1, Eliseos J. Mucaki1, Ami M. Perri1, Ruipeng Lu2, Joan HM. Knoll3,4 and Peter K. Rogan1,2,4,5.
1Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Canada, N6A 2C1, 2Department of Computer Science, Faculty of Science, Western University, London, Canada, N6A 2C1, 3Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, Canada, N6A 2C1, 4Cytognomix Inc. London, Canada, 5Department of Oncology, Schulich School of Medicine and Dentistry, Western University, London, Canada, N6A 2C1
A preprint of this article is published at http://biorxiv.org/content/early/2016/02/09/039206