Browsing articles by " Peter Rogan"

July 1, 2016. Article published on Centromere Detection in Human Metaphase Chromosomes

Jul 1, 2016   //   by Peter Rogan   //   News  //  Comments Off

Our previous preprint in bioRxiv on centromere detection has been published in F1000Research:

Subasinghe A, Samarabandu J, Li Y et al. Centromere detection of human metaphase chromosome images using a candidate based method. F1000Research 2016, 5:1565 (doi:10.12688/f1000research.9075.1)   URL Link.

June 6, 2016. New paper on automated biodosimetry to be published

Jun 4, 2016   //   by Peter Rogan   //   News  //  Comments Off

Our paper, “Radiation Dose Estimation by Automated Cytogenetic Biodosimetry” by Peter K. Rogan, Yanxin Li, Ruth Wilkins, Farrah N. Flegal, and Joan H. M. Knoll, has been accepted for publication in the journal Radiation Protection Dosimetry.

Figure 1. Representative processed metaphase image in ADCI:

Picture1

May 6, 2016. Upcoming public presentations

May 7, 2016   //   by Peter Rogan   //   News  //  Comments Off
  • Peter K. Rogan, Yanxin Li, Ruth Wilkins, Farrah Flegal, Joan HM Knoll. Radiation Dose Estimation by Automated Cytogenetic Biodosimetry, Great Lakes/Canadian Bioinformatics Conference (CCBC/GLBIO). May 16, 2016. University of Toronto (Platform Presentation).
  • Peter K. Rogan. Radiation Dose Estimation by Automated Cytogenetic Biodosimetry. Platform presentation. Great Lakes Chromosome Conference. May 20, 2016. University of Toronto.
  • Peter K. Rogan. Cisplatin Response Prediction in Recurrent Bladder Cancer using Biochemically-inspired Machine Learning. Oral and Poster presentations. 3rd International Molecular Pathological Epidemiology Meeting. May 13, 2016. Dana-Farber Cancer Institute, Boston.
  • Rezaeian I, Mucaki E, Baranova K,  Quang HP, Angelov D, Ilie L, Ngom A, Rueda L, Rogan PK. Predicting outcome of hormone and chemotherapy in the METABRIC breast cancer study. Great Lakes/Canadian Bioinformatics Conference  (GLBIO/CCBC). May 16, 2016. University of Toronto.
  • Baranova K, Mucaki EJ, Angelov D, Lizotte D, and Rogan PK. Cisplatin Response Prediction in Recurrent Bladder Cancer using Biochemically-inspired Machine Learning. Great Lakes/Canadian Bioinformatics Conference (GLBIO/CCBC). May 16, 2016. University of Toronto.
  • Lu R and Rogan PK. Predicting cis-regulation in human promoters by information density-based clustering of heterotypic transcription factor binding sites. Great Lakes/Canadian Bioinformatics Conference  (GLBIO/CCBC). May 16, 2016. University of Toronto.

April 28, 2016. Press release

Apr 28, 2016   //   by Peter Rogan   //   News  //  Comments Off

The University of Western Ontario has issued a press release about our studies describing a unified framework for prioritization of mutations in breast and ovarian cancer. PressreleaseApril282016JPG

Other press outlets:

 

April 26, 2016. Grant funding received for chromosome structure studies using Cytognomix ab initio scDNA probes

Apr 26, 2016   //   by Peter Rogan   //   News  //  Comments Off

Discovery Grant from Natural Sciences and Engineering Research Council received for “Unravelling the metaphase epigenome: Differences in DNA accessibility between homologous chromosomes.” Joan Knoll, Principal Applicant and Peter Rogan, Co-applicant have been awarded 5 years of funding (2016-21) for this project.

April 11, 2016. New paper on analysis of variants of uncertain significance in hereditary breast & ovarian cancer

Apr 11, 2016   //   by Peter Rogan   //   News  //  Comments Off

BMCMedGenomics

 

Our paper, which describes a generalized information theory-based approach for mutation analysis of protein-nucleic binding sites, has been published:

Mucaki, E, Caminsky N, Perri A, Lu R, Laederach A, Halvorsen, M, Knoll, JHM, Rogan PK. A unified analytic framework for prioritization of non-coding variants of uncertain significance in heritable breast and ovarian cancer, BMC Medical Genomics, 9:19, 2016. DOI: 10.1186/s12920-016-0178-5.   (link to paper)   (PubMed citation)

 

 

March 29, 2016. New publication on cost effectiveness of gene expression microarray testing in cancer diagnosis

Mar 30, 2016   //   by Peter Rogan   //   News  //  Comments Off

Through a pan-Canadian collaboration led by Greg Zaric, we have published:

Cost-effectiveness of using a gene expression profiling test to aid in identifying the primary tumour in patients with cancer of unknown primary. M B Hannouf, E Winquist, S M Mahmud, M Brackstone, S Sarma, G Rodrigues, P Rogan, J S Hoch and G S Zaric.

The Pharmacogenomics Journal advance online publication 29 March 2016;  doi: 10.1038/tpj.2015.94  (Link)

March 23, 2016. Final version of article about prioritizing mutations in inherited breast cancer is online

Mar 23, 2016   //   by Peter Rogan   //   News  //  Comments Off

Peer-reviewed article in Early View in the journal Human Mutation:   Link

Earlyview

March 15, 2015. Funding from the Build-in-Canada Innovation Program

Mar 16, 2016   //   by Peter Rogan   //   News  //  Comments Off

Cytognomix pre-qualifies for funding from Build in Canada Innovation Program. Our proposal to test the Automated Dicentric Chromosome Identifier with Health Canada and Canadian Nuclear Laboratories has been approved by Public Works and Government Services Canada (link).

BCIP announcement

March 10, 2016. New paper accepted on prioritization strategy for gene variants of uncertain significance in breast/ovarian cancer

Mar 10, 2016   //   by Peter Rogan   //   News  //  Comments Off

Our paper:

“A unified analytic framework for prioritization of non-coding variants of uncertain significance in heritable breast and ovarian cancer,” by
Eliseos J. Mucaki; Natasha G. Caminsky; Ami M. Perri; Ruipeng Lu; Alain Laederach; Matthew Halvorsen; Joan H.M. Knoll; and Peter K. Rogan

has been accepted for publication in the journal, BMC Medical Genomics.

A preprint of this article is currently available at BioRxiv:  http://biorxiv.org/content/early/2015/11/11/031419.

February 16, 2016. New publication on inherited breast and ovarian cancer

Feb 16, 2016   //   by Peter Rogan   //   News  //  Comments Off

Our new paper on interpretation of gene variants in inherited breast and ovarian cancer has been accepted for publication in the journal, Human Mutation as a Research Article.

“Prioritizing variants in complete Hereditary Breast and Ovarian Cancer (HBOC) genes in patients lacking known BRCA mutations,” by Natasha G. Caminsky1, Eliseos J. Mucaki1, Ami M. Perri1, Ruipeng Lu2, Joan HM. Knoll3,4 and Peter K. Rogan1,2,4,5.

1Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Canada, N6A 2C1, 2Department of Computer Science, Faculty of Science, Western University, London, Canada, N6A 2C1, 3Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, Canada, N6A 2C1, 4Cytognomix Inc. London, Canada, 5Department of Oncology, Schulich School of Medicine and Dentistry, Western University, London, Canada, N6A 2C1

A preprint of this article is published at http://biorxiv.org/content/early/2016/02/09/039206