{"id":4764,"date":"2020-08-31T04:57:25","date_gmt":"2020-08-31T04:57:25","guid":{"rendered":"http:\/\/www.cytognomix.com\/?p=4764"},"modified":"2020-08-31T04:57:56","modified_gmt":"2020-08-31T04:57:56","slug":"aug-31-2020-presentation-at-the-2020-american-society-of-human-genetics-meeting","status":"publish","type":"post","link":"https:\/\/www.cytognomix.com\/?p=4764","title":{"rendered":"Aug. 31, 2020. Presentation at the 2020 American Society of Human Genetics meeting"},"content":{"rendered":"

We are giving a platform<\/strong> presentation at the upcoming American Society of Human Genetics virtual meeting #ASHG2020<\/a><\/p>\n

Session: Personalized Medicine Approaches in Healthcare.<\/p>\n

Paper: Pathway-extended gene expression signatures integrate novel biomarkers that improve predictions of responses to kinase inhibitors<\/strong><\/p>\n

P. K. Rogan(1,2), A. J. Bagchee-Clark(1), E. J. Mucaki(1). 1. Department of Biochemistry, University of Western Ontario and 2. CytoGnomix Inc., London ON Canada<\/p>\n

\"\"<\/a><\/p>\n

Abstract: Individualized chemotherapy selection in cancer potentially maximizes drug efficacy while minimizing drug toxicity. Despite the knowledge of many pharmacogenetic biomarkers, inter-individual variability in response to chemotherapeutic response has limited the success of the approach. We derive multi-gene expression signatures that predict individual patient responses to tyrosine kinase inhibitors (TKIs): erlotinib, gefitinib, sorafenib, sunitinib, lapatinib and imatinib. Gene models for TKIs implicated from the published literature tend to predict either sensitivity or resistance to TKIs well (but not both). This
\nissue was addressed with a systems biology-based strategy that expanded with candidate gene products related to these genes in these models through biochemical pathways and interactions. Using patient transcriptome data, these Pathway-Extended (PE) models predicted responses for individual patients that matched observed outcomes at accuracies of 65% (imatinib), 71% (lapatinib and gefitinib), 78% (sunitinib), 83% (erlotinib) and 89% (sorafenib). After training and evaluating many extended signatures, those with the strongest predictive performance were composed primarily of pathway-related genes that according to post-hoc analysis were clearly implicated in cancer phenotypes. Machine learning-based PE expression signatures display strong efficacy in predicting both sensitivity and specificity in patients through incorporation
\nof novel cancer biomarkers.<\/p>\n

#genomics<\/a>\u00a0#medicine<\/a>\u00a0#chemotherapy<\/a>\u00a0#cancertreatment<\/a>\u00a0#kinaseinhibitors<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

We are giving a platform presentation at the upcoming American Society of Human Genetics virtual meeting #ASHG2020 Session: Personalized Medicine Approaches in Healthcare. Paper: Pathway-extended gene expression signatures integrate novel biomarkers that improve predictions of responses to kinase inhibitors P. K. Rogan(1,2), A. J. Bagchee-Clark(1), E. J. Mucaki(1). 1. Department of Biochemistry, University of Western […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[],"_links":{"self":[{"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/posts\/4764"}],"collection":[{"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4764"}],"version-history":[{"count":2,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/posts\/4764\/revisions"}],"predecessor-version":[{"id":4767,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/posts\/4764\/revisions\/4767"}],"wp:attachment":[{"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4764"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4764"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4764"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}