{"id":4755,"date":"2020-08-07T21:01:24","date_gmt":"2020-08-07T21:01:24","guid":{"rendered":"http:\/\/www.cytognomix.com\/?p=4755"},"modified":"2020-08-07T21:02:00","modified_gmt":"2020-08-07T21:02:00","slug":"august-7-2020-publication-of-novel-molecular-mechanism-of-severe-rna-viral-lung-infections","status":"publish","type":"post","link":"https:\/\/www.cytognomix.com\/?p=4755","title":{"rendered":"August 7, 2020. Publication of novel molecular mechanism of severe RNA-viral lung infections"},"content":{"rendered":"<p>We have described and provide evidence for an explanation for how rapid onset, severe RNA viral infections, such as SARS-CoV-2 or Influenza, may develop:<\/p>\n<p style=\"padding-left: 40px;\"><span class=\"article-title-and-info in-article-box\">Rogan PK, Mucaki EJ and Shirley BC.<strong> A proposed molecular mechanism for pathogenesis of severe RNA-viral pulmonary infections.<\/strong><\/span>\u00a0<i>F1000Research<\/i>\u00a02020,\u00a0<b>9<\/b>:943 (<a href=\"https:\/\/doi.org\/10.12688\/f1000research.25390.1\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.12688\/f1000research.25390.1<\/a>)<\/p>\n<div dir=\"ltr\"><span style=\"font-family: arial, helvetica, sans-serif;\"><span class=\"gmail_default\">There is a<\/span><span class=\"gmail_default\">n accompanying i<strong>nfographic describing the mechanism<\/strong>, which is cited in the article:<\/span><\/span><\/div>\n<div dir=\"ltr\" style=\"padding-left: 40px;\"><a href=\"https:\/\/figshare.com\/articles\/A_proposed_molecular_mechanism_for_pathogenesis_of_severe_RNA-viral_pulmonary_infections\/12718799\/1\" target=\"_blank\" rel=\"noopener noreferrer\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/figshare.com\/articles\/A_proposed_molecular_mechanism_for_pathogenesis_of_severe_RNA-viral_pulmonary_infections\/12718799\/1&amp;source=gmail&amp;ust=1596916467620000&amp;usg=AFQjCNHXsOLPJnQ4r-wK-zf8zTc27B4Jfg\">https:\/\/figshare.com\/articles\/<wbr \/>A_proposed_molecular_<wbr \/>mechanism_for_pathogenesis_of_<wbr \/>severe_RNA-viral_pulmonary_<wbr \/>infections\/12718799\/1<\/a><\/div>\n<div dir=\"ltr\"><\/div>\n<div dir=\"ltr\"><span style=\"font-family: arial, helvetica, sans-serif;\">Finally, the paper cites this <strong>data archive that contains our genomic analyses and related software programs<\/strong>:<\/span><\/div>\n<div dir=\"ltr\" style=\"padding-left: 40px;\">Zenodo: Characteristics of human and viral RNA binding sites and site clusters recognized by SRSF1 and RNPS1.\u00a0<a id=\"m_4264933979869254727gmail-d2914e3358\" href=\"http:\/\/doi.org\/10.5281\/zenodo.3737089\" target=\"_blank\" rel=\"noopener noreferrer\" saferedirecturl=\"https:\/\/www.google.com\/url?q=http:\/\/doi.org\/10.5281\/zenodo.3737089&amp;source=gmail&amp;ust=1596916467621000&amp;usg=AFQjCNHesBkwKSLnIQMUzN6MLBdBaYr7uA\" class=\"broken_link\">http:\/\/doi.org\/10.5281\/<wbr \/>zenodo.3737089<\/a><\/div>\n<div dir=\"ltr\"><\/div>\n<div dir=\"ltr\"><\/div>\n<div dir=\"ltr\"><\/div>\n<div dir=\"ltr\"><\/div>\n<div dir=\"ltr\"><\/div>\n<div dir=\"ltr\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>We have described and provide evidence for an explanation for how rapid onset, severe RNA viral infections, such as SARS-CoV-2 or Influenza, may develop: Rogan PK, Mucaki EJ and Shirley BC. A proposed molecular mechanism for pathogenesis of severe RNA-viral pulmonary infections.\u00a0F1000Research\u00a02020,\u00a09:943 (https:\/\/doi.org\/10.12688\/f1000research.25390.1) There is an accompanying infographic describing the mechanism, which is cited in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[],"_links":{"self":[{"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/posts\/4755"}],"collection":[{"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4755"}],"version-history":[{"count":2,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/posts\/4755\/revisions"}],"predecessor-version":[{"id":4757,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/posts\/4755\/revisions\/4757"}],"wp:attachment":[{"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4755"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4755"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4755"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}