{"id":4537,"date":"2018-09-12T02:01:18","date_gmt":"2018-09-12T02:01:18","guid":{"rendered":"http:\/\/www.cytognomix.com\/?p=4537"},"modified":"2018-09-25T13:11:23","modified_gmt":"2018-09-25T13:11:23","slug":"sept-11-2018-new-publication-about-promoter-gene-variants-in-brca1-and-brca2-that-alter-gene-expression","status":"publish","type":"post","link":"https:\/\/www.cytognomix.com\/?p=4537","title":{"rendered":"Sept. 11, 2018. New publication about promoter gene variants in BRCA1 and BRCA2 that alter gene expression"},"content":{"rendered":"<p>In a collaboration with the ENIGMA Consortium members, we have used bioinformatic and functional genomic analysis to identify gene variants that affect the expression of the BRCA1 and BRCA2 genes. The article is:<\/p>\n<p>Burke LJ, Sevcik J, Gambino G1, Tudini E, Mucaki EJ, Shirley BC, Whiley P, Parsons M, DeLeeneer K, Guti\u00e9rrez-Enr\u00edquez S, Pena MS, Caputo S, Santana dos Santos E, Soukupova J, Janatova M,\u00a0 Zemankova P, Lhotova K, Stolarova L, Borecka M, ENIGMA consortium, Edwards S, Blok R, Hansen TvO, Diez O, Vega A, Claes K, Rouleau E, , Radice P, Peterlongo P, Rogan PK, Caligo M, Spurdle AB and Brown MA.<strong> <em>BRCA1<\/em> and <em>BRCA2<\/em> 5\u2019 non-coding region variants identified in breast cancer patients alter promoter activity and protein binding<\/strong>, Human Mutation.<\/p>\n<p>Link to full text of accepted paper:\u00a0 \u00a0<a href=\"http:\/\/www.cytognomix.com\/?attachment_id=4541\">http:\/\/www.cytognomix.com\/?attachment_id=4541<\/a><\/p>\n<p>Permanent link:\u00a0\u00a0<a href=\"https:\/\/doi.org\/10.1002\/humu.23652\" class=\"broken_link\">https:\/\/doi.org\/10.1002\/humu.23652<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a collaboration with the ENIGMA Consortium members, we have used bioinformatic and functional genomic analysis to identify gene variants that affect the expression of the BRCA1 and BRCA2 genes. The article is: Burke LJ, Sevcik J, Gambino G1, Tudini E, Mucaki EJ, Shirley BC, Whiley P, Parsons M, DeLeeneer K, Guti\u00e9rrez-Enr\u00edquez S, Pena MS, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[],"_links":{"self":[{"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/posts\/4537"}],"collection":[{"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4537"}],"version-history":[{"count":3,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/posts\/4537\/revisions"}],"predecessor-version":[{"id":4544,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/posts\/4537\/revisions\/4544"}],"wp:attachment":[{"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4537"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4537"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}