{"id":2709,"date":"2013-03-26T21:32:14","date_gmt":"2013-03-26T21:32:14","guid":{"rendered":"http:\/\/www.cytognomix.com\/?p=2709"},"modified":"2014-03-29T03:31:50","modified_gmt":"2014-03-29T03:31:50","slug":"march-26-2013-new-article-published-on-chromosome-centromere-structure-and-composition","status":"publish","type":"post","link":"https:\/\/www.cytognomix.com\/?p=2709","title":{"rendered":"March 26, 2013. New article published on chromosome centromere structure and composition."},"content":{"rendered":"<p><a href=\"http:\/\/www.cytognomix.com\/wp-content\/uploads\/2013\/03\/224037.jpg\"><img loading=\"lazy\" class=\"alignleft size-thumbnail wp-image-2715\" title=\"CytogenGenomeRes\" src=\"http:\/\/www.cytognomix.com\/wp-content\/uploads\/2013\/03\/224037-150x150.jpg\" alt=\"\" width=\"150\" height=\"150\" \/><\/a>Khan W.A., Chisholm R., Tadayyon S., Subasinghe A., Norton P., Samarabandu J., Johnston L.J., Knoll J.H., Rogan P.K. <strong>Relating Centromeric Topography in Fixed Human Chromosomes to \u03b1-Satellite DNA and CENP-B Distribution<\/strong>.<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23548580\" target=\"_blank\"> <em>Cytogenetics and Genome Research,<\/em> 2013 (DOI: 10.1159\/000348744)<\/a>.<\/p>\n<div style='display:none;'><!--eb8df65de3db891cb9c9adadfbe09e76--><a href=\"http:\/\/www.omnibeat.com\/linxlabs\/cat\/instant-loan-direct-lender\" class=\"broken_link\">instant loan direct lender<\/a><!--\/eb8df65de3db891cb9c9adadfbe09e76--><\/div>\n<h3>Abstract<\/h3>\n<p>Despite extensive analyses on the centromere and its associated proteins, detailed studies of centromeric DNA structure have provided limited information about its topography in condensed chromatin. We have developed a method with correlative fluorescence light microscopy and atomic force microscopy that investigates the physical and structural organization of \u03b1-satellite DNA sequences in the context of its associated protein, CENP-B, on human metaphase chromosome topography. Comparison of centromeric DNA and protein distribution patterns in fixed homologous chromosomes indicates that CENP-B and \u03b1-satellite DNA are distributed distinctly from one another and relative to observed centromeric ridge topography. Our approach facilitates correlated studies of multiple chromatin components comprising higher-order structures of human metaphase chromosomes.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Khan W.A., Chisholm R., Tadayyon S., Subasinghe A., Norton P., Samarabandu J., Johnston L.J., Knoll J.H., Rogan P.K. Relating Centromeric Topography in Fixed Human Chromosomes to \u03b1-Satellite DNA and CENP-B Distribution. Cytogenetics and Genome Research, 2013 (DOI: 10.1159\/000348744). instant loan direct lender Abstract Despite extensive analyses on the centromere and its associated proteins, detailed studies [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/posts\/2709"}],"collection":[{"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2709"}],"version-history":[{"count":5,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/posts\/2709\/revisions"}],"predecessor-version":[{"id":3190,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=\/wp\/v2\/posts\/2709\/revisions\/3190"}],"wp:attachment":[{"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2709"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2709"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cytognomix.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2709"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}